Uruguay scored in the sixth minute with a spectacular free-kick from Nicolas de la Cruz inside the near post.
Light blue Darwin Núñez doubled that advantage in the 33rd minute when he headed in a Luis Suárez cross and threatened to extend the lead further.
However, after starting on the back foot, Canada had a chance to grow into the game and close in on the goal just past the hour mark. However, Uruguayan goalkeeper Sergio Roche scored a corner kick past Jonathan David’s low shot.
In Group F with Belgium, Morocco and Croatia, Canada will have to make final preparations before qualifying for the World Cup for the first time since 1986. Reds Play against Japan from Dubai on November 17th.